Role of Neurogenesis and Oxidative Stress in Epilepsy (Study on Plasma Brain Derived Neurotrophic Factor and Malondialdehyde Level)

BACKGROUND: Epilepsy is a neurological disorder. Its incidence in Indonesia was 700,000–1,400,000 cases and 40–50% occurred children. About 30–40% of children had uncontrolled seizures. Biomarkers are needed to assess the prognostic value patients with epilepsy. Malondialdehyde (MDA) brain-derived neurotrophic factor (BDNF) one biomarkers related epilepsy see effect oxidative stress neuroplasticity. AIM: The objective study examine cut off plasma BDNF MDA level; compare levels controlled patients. METHODS: research usedanalytic observational cross-sectional approach. Number respondents 30 who came Ulin Hospital Banjarmasin. Respondents were divided into two groups (controlled epilepsy). Blood examined for spectrophotometer ELISA. Data analyzed by t-test 95% confidence level. RESULTS: 11 found group 19 result showed that there significant differences between type therapy developmental disorders/other diseases status. There no status epilepsy), also CONCLUSION: